Medical

Question

  1. Why we should give the methanol poisoning patient ethanol to drink?

2. How about the dose of ethanol drink?

Answer

This blocks toxicity from methanol and can prevent further poisoning.  If IV ethanol is available, it can be used as a substitute for oral ethanol, so long as it is administered under medical supervision.

For adults, give them an initial “loading dose” of 1.8 mL of spirits (spirits with a minimum of 43% (86-proof) ethanol content) per 1 kg of body weight (i.e., for a 70 kg adult, administer three 42 mL shots) of spirits such as vodka, gin, or whisky, with a maintenance dose of 0.40 mL/kg per hour. (i.e., for a 70 kg adult, one 42 mL shot per hour).  To simplify:  for an average-sized adult weighing 70kg, administer a loading dose of 126mL up-front, and 28ml/hour thereafter.

In the U.S., this would equate to giving an adult patient an initial loading dose of 0.06 ounces of spirits (spirits with a minimum of 43% (86-proof) ethanol content) for each 2.2 lbs of body weight (i.e., for an adult who weighs 154 lbs, administer three shots of spirits at 1.4 oz per shot), with a maintenance dose per hour of 0.01 oz/lb (i.e., for a 154 lb adult, administer one 1.50 oz shot per hour).  To simplify:  for an average-sized adult weighing 154 lbs, administer a loading dose of 4.20 ounces up-front, and 1.50 ounces/hour thereafter.  This will stop the poisoning from getting worse while transferring for haemodialysis.

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